Fig. 4.

MSOT imaging and comparison of SMA subtypes/current treatment. a) MSOT parameters (collagen_mean, lipid_mean, HbT) and MSOT SWL 800 nm signal intensities were compared between SMA type I, II, and III using Kruskal-Wallis test, due to the very limited sample size (n = 2 SMA I, n = 4 SMA II, and n = 4 SMA III patients). p value ≤ 0.05 was regarded as statistically significant. b) Coll = collagen, Lip = lipid, MSOT parameters (coll_mean, lip_mean, HbT, lip_max, coll_max) and MSOT SWL 800 nm signal intensities were compared between SMA patients treated with and without Nusinersen using unpaired students t-test with Welch’s correction if appropriate (n = 5 SMA patients with and n = 5 with no treatment). The thin lines mark the density curves of the violin plot. p value ≤ 0.05 was regarded as statistically significant.