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. 2021 Nov 5;23(1):6. doi: 10.3892/ol.2021.13124

Figure 4.

Figure 4.

Treatment response to different doses of irradiation of G2 patient-derived PCa organoid growth. (A) Representative brightfield images of G2 PCa organoids [patients 6 and 13; both grade group 2; both Gleason score, 7 (3+4)]. Scale bar, 100 µm. (B) OFC was calculated in duplicate wells per treatment [patient 6; treatment F(3,4)=0.6917, P=0.6032]. Bonferroni post hoc analysis was performed to determine simple factor effects. (C) Quantification of the average diameter was calculated using ≥30 organoids from duplicate wells/treatment [patient 6; treatment F(3,136)=22.11, P<0.0001]. (D) OFC was calculated in duplicate wells/treatment [patient 13; treatment F(3,4)=29.7, P=0.0034]. (E) Quantification of the average diameter of ≥30 organoids from duplicate wells/treatment (patient 13). One-way ANOVA followed by Bonferroni multiple comparisons [treatment F(3,136)=18.89, P<0.0001]. The data are reported as mean ± SD of duplicate experiments. *P<0.05; **P<0.01, ***P<0.001 vs. CTRL. G, generation; PCa, prostate cancer; CTRL, control.