Table II.
Clinicopathological and molecular characteristics of five cases of defective mismatch repair in biliary cancer.
| Item | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|
| Age, years | 55 | 93 | 60 | 62 | 76 |
| Sex | Male | Female | Female | Male | Male |
| Location | iCCA | dCCA | dCCA | pCCA | ampCA |
| Previous history of cancer | None | None | None | None | None |
| Family history | None | None | None | None | None |
| Immunohistochemistry | dMLH1/PMS2 | dMSH2/MSH6 | dMSH6 | dPMS2 | dPMS2 |
| MSS status | MSI-H | MSI-H | Unmeasurable | MSS | MSS |
| BAT-25 | + | + | − | − | |
| BAT-26 | + | + | − | − | |
| NR-21 | + | + | − | − | |
| MONO-27 | + | − | − | − | |
| NR-24 | + | + | − | − | |
| Main differentiation | Well | Moderate | Poor | Well | Moderate |
| UICC stage | 2 | 3A | 1 | 3C | 3A |
| Resection margin | 0 | 0 | 1 | 0 | 0 |
| Recurrence (location) | + (Lymph node) | − | − | + (Pulmonary) | − |
| Overall survival, months | 17 | 6 | 48 | 37 | 34 |
| Circumstance of death | DOD | DID | DID | DOD | DID |
UICC, Union for International Cancer Control; CCA, cholangiocarcinoma; iCCA, intrahepatic CCA; pCCA, perihilar CCA; dCCA, distal CCA; ampCA, ampullary carcinoma; d, defective; MLH1, mutL homolog 1; PMS2, mismatch repair endonuclease PMS2; MSH, MutS homolog; MSI-H, microsatellite instability-high; MSS, microsatellite stability; DOD, died of disease; DID, died with intercurrent disease.