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. 2021 Nov 2;10(22):8138–8150. doi: 10.1002/cam4.4106

TABLE 3.

IC50 values of the small molecule kinase inhibitors used in this study on the KAIMRC1 cell line

Inhibitors Category Pathways IC50
FPA124 Kinase inhibitors Akt 42.13
10‐DEBC hydrochloride mTOR/Akt 11.63
API‐2 Akt 0.88
AG490 JAK2/STAT 21.10
ZM449829 STAT5 12.78
Thioridazine hydrochloride Stem cell modulator mTOR/Akt/PI3K 10.42
KU55933 Epigenome mTOR 29.33
L002 STAT3 10.4
Mitoxantrone Topoisomerase II inhibitor Antineoplastic agent 0.36
Doxorubicin Anthracycline 0.24
Ruxolitinib Kinase inhibitors JAK1 and JAK2 0.94