Table 2.

Permeability surface area (PS, 10⁻⁴ min⁻¹) against age (years), Fazekas score, stroke subtype, mean arterial pressure (mmHg), hypertension status, pulse pressure (mmHg) and smoking status in each tissue type of interest. (WM = white matter, CI = confidence interval, MAP = mean arterial pressure).

	Tissue PS associations using Fazekas score
Tissue	Variable	B coefficient	95% CI	p-value
Normal appearing WM	Age	−0.044	−0.070 to −0.018	<0.001
	Fazekas score	0.150	−0.008 to 0.308	0.062
	Stroke subtype	−0.398	−0.868 to 0.072	0.097
	MAP	−0.006	−0.023 to 0.011	0.500
	Hypertension	0.411	−0.141 to 0.963	0.144
	Pulse pressure	0.004	−0.009 to 0.017	0.562
	Smoking status	−0.423	−0.942 to 0.096	0.109
WM Hyperintensities	Age	−0.030	−0.058 to −0.002	0.035
	Fazekas score	0.092	−0.081 to 0.265	0.296
	Stroke subtype	−0.039	−0.550 to 0.473	0.882
	MAP	0.002	−0.017 to 0.021	0.862
	Hypertension	0.309	−0.294 to 0.912	0.314
	Pulse pressure	0.002	−0.013 to 0.016	0.810
	Smoking status	−0.028	−0.594 to 0.537	0.922
Grey matter	Age	−0.044	−0.068 to −0.019	<0.001
	Fazekas score	0.150	0.001 to 0.299	0.049
	Stroke subtype	−0.285	−0.729 to 0.159	0.207
	MAP	−0.004	−0.020 to 0.013	0.650
	Hypertension	0.207	−0.315 to 0.729	0.434
	Pulse pressure	0.010	−0.002 to 0.023	0.103
	Smoking status	0.148	−0.343 to 0.638	0.553
Recent stroke lesion	Age	0.019	−0.067 to 0.105	0.666
	Fazekas score	−0.067	−0.596 to 0.461	0.801
	Stroke subtype	−2.017	−3.621 to −0.413	0.014
	MAP	0.027	−0.032 to 0.086	0.366
	Hypertension	2.195	0.194 to 4.197	0.032
	Pulse pressure	−0.020	−0.064 to 0.025	0.385
	Smoking status	0.774	−0.965 to 2.514	0.380