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. 2021 Nov 11;23(1):13. doi: 10.3892/ol.2021.13131

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Copyright: © Kakabadze et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Modeling of tongue squamous cell carcinoma in rats. (А) Rat tongue lesions induced by 4-nitroquinoline 1-oxide: (a) Normal tongue, and (b) 1, (c) 1.5 and (d) 2 months from the initiation of squamous cell carcinoma modeling. (B) Carcinoma in situ (black arrows) after an observation period of 2 months (hematoxylin and eosin staining; magnification, ×400). (C) High expression of cyclin D1 (magnification, ×400). (D) Low expression of E-cadherin (magnification, ×400). (E) High expression of Ki-67 (magnification, ×400). (F) High expression of p63 (magnification, ×400).