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. 2021 Dec 15;201:108833. doi: 10.1016/j.neuropharm.2021.108833

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — UBP145 inhibits NMDAR-mediated EPSCs from CA1 pyramidal cell and SR IN in WTs.

(A) NMDAR EPSCs from CA1 pyramidal cells in WTs (n = 5). Representative traces (right) showing NMDAR EPSCs from baseline period (a) and at the end of UBP145 application (b) (B) UBP145 (10 μM) inhibited NDMAR EPSCs by 38.4 ± 2.6%. (C) Similar to panel A but NMDAR EPSCs from SR IN in WTs (closed circles, n = 4) and KOs (open circles, n = 3). (D) NMDAR EPSC from SR IN was significantly inhibited by 10 μM UBP145 in WTs (40.5 ± 3.1%) but not KOs (−5.9 ± 2.4%; ***p = 0.0001, t(5) = 11.06, t-test).