| Safety: cognitive delay ‐ developmental delay |
|
Patient or population: children 9 months to 15 years old
Setting: general population
Intervention: MMR vaccine
Comparison: unvaccinated |
| Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect
(95% CI) |
№ of participants
(studies) |
Certainty of the evidence
(GRADE) |
| Risk of cognitive delay ‐
developmental delay amongst
unvaccinated |
Risk of cognitive delay ‐
developmental delay amongst
vaccinated |
| Cohort study ‐ MDI‐BSID II 24th month, MMR |
Study population |
OR 1.35
(0.15 to 12.07) |
337
(1 observational study) |
⊕⊕⊝⊝
LOW |
| 0 per 1000 |
0 per 1000
(0 to 0) |
| Cohort study ‐ MDI‐BSID II 36th month, MMR |
Study population |
OR 0.37
(0.03 to 4.28) |
337
(1 observational study) |
⊕⊕⊝⊝
LOW |
| 0 per 1000 |
0 per 1000
(0 to 0) |
| Cohort study ‐ Raven 5th year, MMR |
Study population |
OR 1.22
(0.23 to 6.51) |
337
(1 observational study) |
⊕⊕⊝⊝
LOW |
| 0 per 1000 |
0 per 1000
(0 to 0) |
| Cohort study ‐ WISC‐R verbal 6th year, MMR |
Study population |
OR 1.23
(0.09 to 16.92) |
337
(1 observational study) |
⊕⊕⊝⊝
LOW |
| 0 per 1000 |
0 per 1000
(0 to 0) |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; MDI‐BSID II: Mental Development Index of Bayley Scales of Infant Development, second edition; MMR: measles, mumps, rubella vaccine; OR: odds ratio; WISC‐R: Wechsler Intelligence Scale for Children, Revised Form |
|
GRADE Working Group grades of evidence
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. |
