Summary of findings 17. Safety: hay fever, rhinoconjunctivitis, hypersensitivity/allergy.
| Safety: hay fever, rhinoconjunctivitis, hypersensitivity/allergy | |||||
| Patient or population: children 9 months to 15 years old Setting: general population Intervention: MMR vaccine Comparison: unvaccinated | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk of hay fever, rhinoconjunctivitis, hypersensitivity/allergy amongst unvaccinated | Risk of hay fever, rhinoconjunctivitis, hypersensitivity/allergy amongst vaccinated | ||||
| Cohort study ‐ rhinoconjunctivitis | Study population | OR 0.64 (0.19 to 2.11) | 489 (1 observational study) | ⊕⊕⊝⊝ LOW | |
| 211 per 1000 | 146 per 1000 (48 to 360) | ||||
| Cohort study ‐ hypersensitivity/allergy | Study population | OR 0.63 (0.14 to 2.77) | 544 (1 observational study) | ⊕⊕⊝⊝ LOW | |
| 429 per 1000 | 321 per 1000 (95 to 675) | ||||
| Case control ‐ hay fever | Study population | OR 1.16 (0.92 to 1.45) | 0 cases, 0 controls (2 observational studies) | ⊕⊕⊝⊝ LOW | |
| 0 per 1000 | 0 per 1000 (0 to 0) | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MMR: measles, mumps, rubella vaccine; OR: odds ratio | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||
1Upgraded one level due to non‐critical risk of bias in the study.