Comparison 2. Effectiveness against mumps.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Cohort studies ‐ Jeryl Lynn strain	9		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1.1 1 dose	6	9915	Risk Ratio (M‐H, Random, 95% CI)	0.28 [0.13, 0.62]
2.1.2 2 doses	5	7792	Risk Ratio (M‐H, Random, 95% CI)	0.14 [0.07, 0.27]
2.1.3 Unspecified number of doses	4	2011	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.14, 0.35]
2.1.4 Household contacts	3	1036	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.13, 0.49]
2.2 Cohort studies ‐ Urabe strain	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.2.1 Unspecified numbers or at least 1 dose	4	2721	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.12, 0.44]
2.3 Cohort studies ‐ Rubini strain	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.3.1 Unspecified numbers or at least 1 dose	4	4219	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.55, 1.65]
2.4 Cohort studies ‐ mumps strain not reported or mixed	2	769	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.29, 0.94]
2.5 Cohort studies ‐ 3 doses vs 2 doses	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.5.1 3 doses vs 2 doses	2	5417	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.33, 1.05]
2.6 Case‐control studies ‐ Jeryl Lynn strain	4		Odds Ratio (IV, Random, 95% CI)	Subtotals only
2.6.1 1 dose	3		Odds Ratio (IV, Random, 95% CI)	0.43 [0.27, 0.70]
2.6.2 2 doses	2		Odds Ratio (IV, Random, 95% CI)	0.19 [0.09, 0.41]
2.6.3 At least 1 dose	4		Odds Ratio (IV, Random, 95% CI)	0.35 [0.25, 0.48]
2.7 Case‐control studies ‐ Jeryl Lynn strain ‐ lab‐confirmed cases	1		Odds Ratio (IV, Random, 95% CI)	Subtotals only
2.7.1 1 dose	1		Odds Ratio (IV, Random, 95% CI)	0.36 [0.22, 0.59]
2.7.2 2 doses	1		Odds Ratio (IV, Random, 95% CI)	0.12 [0.04, 0.37]
2.7.3 At least 1 dose	1		Odds Ratio (IV, Random, 95% CI)	0.35 [0.16, 0.76]
2.8 Case‐control studies ‐ Urabe strain	1		Odds Ratio (IV, Random, 95% CI)	Subtotals only
2.8.1 At least 1 dose	1		Odds Ratio (IV, Random, 95% CI)	0.30 [0.12, 0.75]
2.9 Case‐control studies ‐ Rubini strain	1		Odds Ratio (IV, Random, 95% CI)	Subtotals only
2.9.1 At least 1 dose	1		Odds Ratio (IV, Random, 95% CI)	0.90 [0.43, 1.89]
2.10 Case‐control studies ‐ strain type not reported or any strain	2		Odds Ratio (IV, Random, 95% CI)	Subtotals only
2.10.1 1 dose	1		Odds Ratio (IV, Random, 95% CI)	0.70 [0.22, 2.21]
2.10.2 2 doses	1		Odds Ratio (IV, Random, 95% CI)	0.52 [0.09, 3.16]
2.10.3 At least 1 dose	2		Odds Ratio (IV, Random, 95% CI)	0.50 [0.31, 0.81]