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. 2021 Nov 22;2021(11):CD004407. doi: 10.1002/14651858.CD004407.pub5

Comparison 4. Effectiveness against varicella.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 MMRV randomised clinical trial ‐ any severity 3   Rate Ratio (IV, Random, 95% CI) Subtotals only
4.1.1 2 doses ‐ follow up at 5 years 1   Rate Ratio (IV, Random, 95% CI) 0.05 [0.03, 0.08]
4.1.2 2 doses ‐ follow up between 5 to 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.05 [0.04, 0.06]
4.1.3 2 doses ‐ follow up at 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.05 [0.04, 0.06]
4.2 MMRV randomised clinical trial ‐ moderate/severe cases 3   Rate Ratio (IV, Random, 95% CI) Subtotals only
4.2.1 2 doses ‐ Follow up at 5 years 1   Rate Ratio (IV, Random, 95% CI) 0.00 [0.00, 0.02]
4.2.2 2 doses ‐ Follow up between 5 to 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.01 [0.00, 0.02]
4.2.3 2 doses ‐ Follow up at 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.01 [0.00, 0.02]
4.3 MMR+V randomised clinical trial ‐ any severity 3   Rate Ratio (IV, Random, 95% CI) 0.33 [0.30, 0.36]
4.3.1 2 doses ‐ follow up at 5 years 1   Rate Ratio (IV, Random, 95% CI) 0.35 [0.28, 0.43]
4.3.2 2 doses ‐ follow up between 5 to 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.33 [0.29, 0.38]
4.3.3 2 doses ‐ follow up at 10 years 1   Rate Ratio (IV, Random, 95% CI) 0.33 [0.29, 0.38]
4.4 MMR+V randomised clinical trial ‐ moderate/severe cases 3   Rate Ratio (IV, Fixed, 95% CI) 0.10 [0.08, 0.12]
4.4.1 2 doses ‐ Follow up at 5 years 1   Rate Ratio (IV, Fixed, 95% CI) 0.09 [0.06, 0.14]
4.4.2 2 doses ‐ Follow up between 5 to 10 years 1   Rate Ratio (IV, Fixed, 95% CI) 0.10 [0.07, 0.13]
4.4.3 2 doses ‐ Follow up at 10 years 1   Rate Ratio (IV, Fixed, 95% CI) 0.10 [0.08, 0.14]
4.5 MMR+V randomised clinical trial ‐ severe cases 1   Rate Ratio (IV, Fixed, 95% CI) Subtotals only
4.5.1 2 doses ‐ follow up between 5 to 10 years 1   Rate Ratio (IV, Fixed, 95% CI) 0.05 [0.01, 0.47]
4.6 MMRV cohort study 4   Risk Ratio (IV, Random, 95% CI) Subtotals only
4.6.1 One dose ‐ any severity 4   Risk Ratio (IV, Random, 95% CI) 0.25 [0.11, 0.59]
4.6.2 Two doses ‐ any severity 2   Risk Ratio (IV, Random, 95% CI) 0.13 [0.13, 0.14]
4.7 MMRV case‐control 1   Odds Ratio (IV, Random, 95% CI) Subtotals only
4.7.1 Any dose ‐ any severity 1   Odds Ratio (IV, Random, 95% CI) 0.14 [0.07, 0.28]
4.7.2 Any dose ‐ moderate/severe cases 1   Odds Ratio (IV, Random, 95% CI) 0.07 [0.03, 0.17]
4.8 MMR+V case control 3   Odds Ratio (IV, Random, 95% CI) Subtotals only
4.8.1 1 dose ‐ any severity 2   Odds Ratio (IV, Random, 95% CI) 0.14 [0.08, 0.22]
4.8.2 2 doses ‐ any severity 2   Odds Ratio (IV, Random, 95% CI) 0.05 [0.01, 0.14]
4.8.3 Any dose ‐ any severity 2   Odds Ratio (IV, Random, 95% CI) 0.12 [0.08, 0.18]
4.9 MMRV case only ecological method ‐ hospitalisation 3   Rate Ratio (IV, Random, 95% CI) 0.43 [0.34, 0.55]
4.9.1 Age < 1 year ‐ any dose 2   Rate Ratio (IV, Random, 95% CI) 0.52 [0.37, 0.74]
4.9.2 Age 1 to 4 years ‐ any dose 2   Rate Ratio (IV, Random, 95% CI) 0.29 [0.10, 0.85]
4.9.3 Age 5 to 14 years ‐ any dose 2   Rate Ratio (IV, Random, 95% CI) 0.37 [0.19, 0.72]
4.9.4 Age 0 to 14 years ‐ any doses 1   Rate Ratio (IV, Random, 95% CI) 0.53 [0.44, 0.64]
4.10 MMRV case only ecological method ‐ incidence 2   Rate Ratio (IV, Random, 95% CI) 0.24 [0.14, 0.43]
4.10.1 Age < 1 year 1   Rate Ratio (IV, Random, 95% CI) 0.17 [0.12, 0.24]
4.10.2 Age 1 to 4 years ‐ any dose 1   Rate Ratio (IV, Random, 95% CI) 0.08 [0.07, 0.09]
4.10.3 Age 5 to 14 years ‐ any dose 1   Rate Ratio (IV, Random, 95% CI) 0.14 [0.12, 0.16]
4.10.4 Age 0 to 14 years ‐ any doses 1   Rate Ratio (IV, Random, 95% CI) 0.65 [0.53, 0.80]