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. 2021 Nov 22;2021(11):CD004407. doi: 10.1002/14651858.CD004407.pub5

Comparison 7. Safety: aseptic meningitis.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
7.1 Case‐control ‐ case cross‐over 3   Odds Ratio (IV, Random, 95% CI) Subtotals only
7.1.1 Case control ‐ Jeryl Lynn ‐ risk interval 0 to 30 days 1   Odds Ratio (IV, Random, 95% CI) 0.85 [0.21, 3.41]
7.1.2 Case crossover ‐ Urabe or Hoshino 2   Odds Ratio (IV, Random, 95% CI) 4.00 [2.23, 7.20]
7.1.3 Case crossover ‐ Jeryl Lynn or Rubini 1   Odds Ratio (IV, Random, 95% CI) 0.60 [0.18, 1.99]
7.2 Self‐controlled case series (SCCS)/person‐time cohort (PT) 5   Rate Ratio (IV, Random, 95% CI) Subtotals only
7.2.1 SCCS ‐ any strain 1   Rate Ratio (IV, Random, 95% CI) 12.40 [3.12, 49.35]
7.2.2 SCCS ‐ Urabe 3   Rate Ratio (IV, Random, 95% CI) 30.71 [13.45, 70.10]
7.2.3 SCCS ‐ Leningrad‐Zageb 1   Rate Ratio (IV, Random, 95% CI) 6.40 [0.78, 52.47]
7.2.4 PT ‐ Jeryl Lynn 1   Rate Ratio (IV, Random, 95% CI) 1.30 [0.66, 2.56]
7.3 Case only ecological method (COEM) 3   Rate Ratio (IV, Random, 95% CI) Subtotals only
7.3.1 COEM ‐ Urabe 1   Rate Ratio (IV, Random, 95% CI) 9.12 [5.73, 14.52]
7.3.2 COEM ‐ Leningrad‐Zagreb 2   Rate Ratio (IV, Random, 95% CI) 18.56 [12.09, 28.51]