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. 2021 Nov 22;2021(11):CD004407. doi: 10.1002/14651858.CD004407.pub5

Comparison 8. Safety: seizures (febrile/afebrile).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
8.1 Cohort studies 2   Rate Ratio (IV, Random, 95% CI) Subtotals only
8.1.1 Within 1 week after vaccination MMR 2   Rate Ratio (IV, Random, 95% CI) 2.45 [2.21, 2.71]
8.1.2 Between 1 to 2 weeks after vaccination MMR 2   Rate Ratio (IV, Random, 95% CI) 3.16 [2.89, 3.46]
8.1.3 > 2 weeks after vaccination MMR 1   Rate Ratio (IV, Random, 95% CI) 0.97 [0.49, 1.94]
8.2 Self‐controlled case series/person‐time cohort 6   Rate Ratio (IV, Random, 95% CI) Subtotals only
8.2.1 Between 1 to 2 weeks after vaccination MMR 5   Rate Ratio (IV, Random, 95% CI) 3.36 [2.65, 4.24]
8.2.2 > 2 weeks after vaccination MMR 3   Rate Ratio (IV, Random, 95% CI) 1.18 [0.93, 1.50]
8.2.3 Between 1 to 2 weeks after vaccination; MMRV 2   Rate Ratio (IV, Random, 95% CI) 6.08 [4.95, 7.47]
8.2.4 between 1 to 2 weeks after vaccination MMR+V 1   Rate Ratio (IV, Random, 95% CI) 3.13 [2.38, 4.10]
8.3 MMRV versus MMR+V 5   Risk Ratio (IV, Random, 95% CI) Subtotals only
8.3.1 from 0 to 42 days after vaccination 5   Risk Ratio (IV, Random, 95% CI) 1.31 [1.19, 1.45]
8.3.2 from 7 to 10 days after vaccination 5   Risk Ratio (IV, Random, 95% CI) 1.98 [1.69, 2.33]
8.4 MMRV versus MMR+V ‐ by brand 5   Risk Ratio (IV, Random, 95% CI) Subtotals only
8.4.1 From 0 to 42 days after vaccination (Priorix) 1   Risk Ratio (IV, Random, 95% CI) 1.95 [0.85, 4.48]
8.4.2 From 7 to 10 days after vaccination (Priorix) 1   Risk Ratio (IV, Random, 95% CI) 1.69 [0.93, 3.07]
8.4.3 From 0 to 42 days after vaccination (ProQuad) 4   Risk Ratio (IV, Random, 95% CI) 1.30 [1.17, 1.44]
8.4.4 From 7 to 10 days after vaccination (ProQuad) 4   Risk Ratio (IV, Random, 95% CI) 2.01 [1.70, 2.38]
8.5 MMRV versus MMR 6   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
8.5.1 From 0 to 42 days after vaccination 5   Risk Ratio (IV, Fixed, 95% CI) 1.53 [1.37, 1.71]
8.5.2 From 7 to 10 days after vaccination 6   Risk Ratio (IV, Fixed, 95% CI) 1.50 [1.36, 1.66]
8.6 MMRV versus MMR ‐ by brand 6   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
8.6.1 From 0 to 42 days after vaccination (Priorix) 2   Risk Ratio (IV, Fixed, 95% CI) 1.28 [1.00, 1.64]
8.6.2 From 7 to 10 days after vaccination (Priorix) 2   Risk Ratio (IV, Fixed, 95% CI) 2.49 [1.66, 3.74]
8.6.3 From 0 to 42 days after vaccination (ProQuad) 3   Risk Ratio (IV, Fixed, 95% CI) 1.60 [1.42, 1.82]
8.6.4 From 7 to 10 days after vaccination (ProQuad) 4   Risk Ratio (IV, Fixed, 95% CI) 1.46 [1.32, 1.61]