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. 2021 Nov 22;2021(11):CD004407. doi: 10.1002/14651858.CD004407.pub5

ca‐Arenz 2005.

Study characteristics
Methods Cohort study ‐ Germany
Participants 55 families and 43 children. Household contacts in families with at least 1 mumps case.
43 exposed children included in the final analysis, of which 25 were female and 18 were male. Median age was 5 years 3 months in measles cases and 6 years 6 months in contacts without measles. None of the included children had a history of measles.
Interventions Vaccination with measles‐containing vaccine
Outcomes Case definition: generalised maculopapular rash with fever 38.4 °C for 3 days and at least 1 of the following signs: cough, coryza, Koplik spots, or conjunctivitis.
Primary case: the first household member who acquired measles.
Co‐primary cases were defined as measles patients who developed a fever within 4 days after the onset of a rash in the primary case.
Secondary cases were confirmed measles patients who developed a fever within 5 to 25 days after the onset of a rash in the primary case.
Contacts were all household members who had contact with measles cases in the household during their infectious period.
Funding Source Government
Notes Insufficient information about vaccine composition (if MMR or bivalent) for household contact study. Screening method was used for vaccine effectiveness assessment in Coburg school population aged older than 5 years. Many important details are missing.
Risk of bias
Bias Authors' judgement Support for judgement
PCS/RCS ‐ exposed cohort selection Unclear risk There was insufficient information.
PCS/RCS ‐ non‐exposed cohort selection Unclear risk There was insufficient information.
PCS/RCS ‐ comparability Unclear risk The cohort was limited to affected classes.
PCS/RCS ‐ assessment of outcome Unclear risk There was insufficient information.
Summary Risk of Bias assessment High risk We had concerns regarding multiple domains such that our confidence in the result is substantially lowered.