| Study characteristics |
| Methods |
Retrospective cohort, Italy; the cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records) |
| Participants |
The analysis included 11,004 children. Children born in the period between 2008 and 2010, who subsequently underwent vaccination in 2009 to 2011 and resident in the territories of the ASL Rome. |
| Interventions |
MMR vaccination: 20.9% did not receive the MMR vaccination; 49% and 30.1% received 1 and 2 doses. |
| Outcomes |
Hospitalisation for measles, mumps, or rubella |
| Funding Source |
Government |
| Notes |
Conclusion: MMR vaccination is effective for the primary prevention of target and not‐targeted infectious diseases and may also limit hospitalisations for respiratory diseases. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| PCS/RCS ‐ exposed cohort selection |
Unclear risk |
Retrospective cohort ‐ by vaccination register |
| PCS/RCS ‐ non‐exposed cohort selection |
Unclear risk |
Retrospective cohort ‐ by vaccination register |
| PCS/RCS ‐ comparability |
Unclear risk |
Possible residual confounding ‐ no data on family income or at least parents’ educational level that could have an impact on vaccination attitude. No data were available on other vaccinations. |
| PCS/RCS ‐ assessment of outcome |
Unclear risk |
There was insufficient information. |
| Summary Risk of Bias assessment |
Unclear risk |
We had concerns regarding at least 1 domain such that some doubt is raised about the results. |
