cb‐Dunlop 1989.

Study characteristics
Methods	Prospective cohort
Participants	335 healthy children aged about 15 months
Interventions	MMR vaccine Trimovax (Mérieux, containing measles strain Schwarz 1000 TCID50, rubella RA 27/3 1000 TCID50, mumps Urabe AM/9 5000 TCID50) versus Measles vaccine Rouvax (Mérieux, containing measles strain Schwarz, 1000 TCID50). Single dose IM or sc administered
Outcomes	Rash, temperature, cough, pallor, diarrhoea, nappy rash, injection site bruise, earache, parotitis, lymphadenopathy, hospitalisation Parental daily diary for 3 weeks and weekly for 3 more weeks
Funding Source	Government
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
PCS/RCS ‐ exposed cohort selection	High risk	Cohort was defined on voluntary basis ‐ probable selection bias
PCS/RCS ‐ non‐exposed cohort selection	High risk	Cohort was defined on voluntary basis ‐ probable selection bias
PCS/RCS ‐ comparability	High risk	No adjustment for confounding
PCS/RCS ‐ assessment of outcome	Unclear risk	No information
Summary Risk of Bias assessment	High risk	We had concerns regarding multiple domains such that our confidence in the result is substantially lowered.