| Study characteristics |
| Methods |
Prospective cohort |
| Participants |
1638 healthy children |
| Interventions |
MMR vaccine MPR (Kitasato Institute, Japan containing measles AIK‐C 5000 TCID50, mumps Hoshino 15000 TCID50, and rubella Takahashi 32000 TCID50)
versus
Measles vaccine (Kitasato Institute, containing measles AIK‐C 25000 TCID50)
versus
Mumps vaccine (Kitasato Institute, containing mumps Hoshino 10000 TCID50) |
| Outcomes |
Temperature, axillary (up to 37.5 °C or up to 39.0 °C), rash (mild, moderate, or severe), lymphadenopathy, parotitis, cough, vomiting, diarrhoea within 28 days after vaccination |
| Funding Source |
Not stated |
| Notes |
Inadequate description of the cohorts |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| PCS/RCS ‐ exposed cohort selection |
Unclear risk |
There was insufficient information ‐ probable selection bias. |
| PCS/RCS ‐ non‐exposed cohort selection |
Unclear risk |
There was insufficient information ‐ probable selection bias. |
| PCS/RCS ‐ comparability |
Unclear risk |
Homogeneous age ‐ there was insufficient information to assess comparability |
| PCS/RCS ‐ assessment of outcome |
High risk |
Self‐reported |
| Summary Risk of Bias assessment |
High risk |
We had concerns regarding multiple domains such that our confidence in the result is substantially lowered. |
