| Study characteristics |
| Methods |
Self‐controlled case series study |
| Participants |
561,089 children aged between 1 and 7 years at the time of vaccination |
| Interventions |
Immunisation with MMR 2 vaccine (Merck, containing measles strain Enders Edmonston, mumps Jeryl Lynn, and rubella Wistar RA 27) during a national immunisation campaign |
| Outcomes |
‐ Encephalitis
‐ Aseptic meningitis
‐ Autism |
| Funding Source |
Mixed (government and pharmaceutical industry) |
| Notes |
Incidence of outcomes during the first 3 months after immunisation was compared with that in the following period (from 3 to 24 months after immunisation). |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| SCCS/PTC ‐ case selection |
Unclear risk |
There was insufficient information. |
| SCCS/PTC ‐ exposure |
Unclear risk |
There was insufficient information. |
| SCCS/PTC ‐ observation and exposure risk period |
Unclear risk |
There was insufficient information. |
| SCCS/PTC ‐ comparability |
Unclear risk |
There was insufficient information. |
| Summary Risk of Bias assessment |
Unclear risk |
We had concerns regarding at least 1 domain such that some doubt is raised about the results. |
