gb‐Taylor 2002.
| Study characteristics | ||
| Methods | Case‐only ecological method ‐ linked to db‐Taylor 1999 | |
| Participants | Children with childhood (core autism N = 278) and atypical autism (N = 195) born between 1979 and 1998 from computerised health registers of children with disabilities in the community and from special school and child psychiatry records, using the same methods and classifications as in their earlier study (db‐Taylor 1999) | |
| Interventions | MMR vaccination (not described) | |
| Outcomes | Recorded bowel problems lasting at least 3 months, age of reported regression of the child's development where it was a feature, and relation of these to MMR vaccination | |
| Funding Source | Government | |
| Notes | Conclusions: these findings provide no support for an MMR‐associated “new variant” form of autism with developmental regression and bowel problems, and offer further evidence against involvement of MMR vaccine in the initiation of autism. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| COEM ‐ case selection | Unclear risk | There was insufficient information. |
| COEM ‐ exposure | Unclear risk | There was insufficient information. |
| COEM ‐ time trend comparison | Unclear risk | There was insufficient information. |
| COEM ‐ comparability | Unclear risk | There was insufficient information. |
ADEM: acute disseminated encephalomyelitis ADI‐R: Autism Diagnostic Interview‐Revised AEFI: adverse events following immunisation AIT: acute immune thrombocytopenia AM: aseptic meningitis ASHIPS: Associations of Statutory Health Insurance Physicians ASD: autism spectrum disorders AR: attack rates BCG: Bacillus Calmette‐Guérin CD: Crohn’s disease CI: confidence interval CIR: Citywide Immunization Registry CSF: cerebrospinal fluid CSTE: Council of State and Territorial Epidemiologist CT: computed tomography DIN: Doctors’ Independent Network DOHMH: Department of Health and Mental Hygiene DPHSS: Department of Public Health and Social Services DPPT: diphtheria, polio, pertussis, and tetanus vaccination DSM‐lV: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition DTP: diphtheria, tetanus, and pertussis EDs: emergency departments EEG: electroencephalograph EPI: Expanded Programmed Immunization FC: febrile convulsion FS: febrile seizures GP: general practice GPRD: General Practice Research Database Hib: Haemophilus influenzae type b HMO: health maintenance organisation HPV: human papillomavirus HSP: Henoch‐Schönlein purpura IBD: inflammatory bowel disease ICD: International Classification of Diseases ICD‐9‐CM: International Classification of Diseases‐Ninth Revision‐Clinical Modification ICD‐10‐CA: International Classification of Diseases, Tenth Revision, Canada ICD‐10‐GM: International Classification of Diseases. Tenth Revision, German Modification IgE: immunoglobulin E IgG: immunoglobulin G IgM: immunoglobulin M IIS: Immunisation Information Systems IM: intramuscular ITP: idiopathic thrombocytopenic purpura KPSC: Kaiser Permanente Southern California MenC: meningitis C MCOs: Managed Care Organizations MuCV: mumps‐containing vaccines MMR: measles, mumps, rubella vaccine MMRV: measles, mumps, rubella, and varicella vaccine MMR+V: measles, mumps, rubella, plus varicella vaccine MR: measles and rubella vaccine MRI: magnetic resonance imaging MS: multiple sclerosis n: number of participants in intervention and control arm or number of cases NIP: National Immunization Program OPV: oral polio vaccine PCR: polymerase chain reaction PDD: pervasive developmental disorder PEP: postexposure prophylaxis RCT: randomised controlled study RCV: rubella‐containing vaccine RNA: ribonucleic acid RT‐PCR: reverse‐transcription polymerase chain reaction SAR: secondary attack rate sc: subcutaneous SCORAD: SCORing Atopic Dermatitis T1D: type 1 diabetes TBE: tick‐borne encephalitis TCID50: Tissue Culture Infectious Dose TP: thrombocytopenic purpura UC: ulcerative colitis V: varicella VE: vaccine effectiveness/efficacy VP: vaccination program VSD: Vaccine Safety Datalink WHO: World Health Organization wks: weeks