| Study | Reason for exclusion |
|---|---|
| Akobeng 1999 | Commentary relating to an excluded study (Wakefield 1998) |
| Andre 1984 | No direct data on MMR, only observation that it may interfere with varicella vaccine |
| Anonymous 1982 | Non‐comparative |
| Anonymous 1997 | Review |
| Anonymous 1998 | No safety data |
| Anonymous 1999 | Review |
| Aozasa 1982 | Not MMR vaccine |
| Asaria 2008 | Review |
| Autret 1996 | Epidemiological survey comparing onset of idiopathic thrombocytopenic purpura following vaccination with MMR compared to M, M, and R |
| Bakker 2001 | Authors attribute school mumps outbreak to bad attenuated MMR vaccine lots; uncertain data about relationship between MMR exposure and symptom onset. |
| Balraj 1995 | Review on mumps vaccine |
| Bawankule 2017 | Vaccine type used not described. |
| Beck 1991 | Assessed safety of MMR vaccination in children allergic to eggs |
| Bedford 2010 | Editorial |
| Beeler 1996 | Case series. Reported data were insufficient to assess causal relationship. |
| Benjamin 1991 | Review |
| Berger 1988a | Serological data only |
| Berger 1988b | Serological data only |
| Berlin 1983 | Surveillance data |
| Bernsen 2008 | No review‐relevant outcomes reported. Study assessed association between MMR infection and atopic disorder. |
| Bhargava 1995 | Non‐comparative |
| Bonanni 2005 | Non‐comparative |
| Borchardt 2007 | Non‐comparative |
| Borgono 1973 | Non‐comparative |
| Boxall 2008 | Non‐comparative |
| Brockhoff 2010 | Non‐comparative |
| Brond 2017 | Monovalent varicella vaccine |
| Bruno 1997 | Compared 2 MMR types |
| Bulik 2018 | Review |
| Buntain 1976 | Case report |
| Buynak 1969 | Non‐comparative |
| Byberg 2017 | Monovalent varicella vaccine |
| Cao 2018 | Vaccine type used is unclear; probably monovalent varicella. |
| Cardenosa 2006 | Non‐comparative |
| Cashman 2018 | Letter |
| Chang 1982 | Serological data only |
| Chang 2017 | Serological data only |
| Chen 1991 | Participants aged over 15 years |
| Chen 2000 | Review |
| Cherian 2010 | Environmental factors associated to incidence of type 1 diabetes mellitus only reported. |
| Chiodo 1992 | Non‐comparative |
| Cinquetti 1994 | Compared 2 types of MMR |
| Contardi 1989 | Non‐comparative |
| Contardi 1992 | Non‐comparative |
| Coplan 2000 | Non‐comparative |
| Coronado 2006 | Case‐fatality rate study |
| Cox 2009 | Letter |
| Curtale 2010 | Non‐comparative |
| Czajka 2009 | Non‐comparative |
| D'Souza 2000 | Non‐comparative |
| Dales 2001 | Non‐comparative |
| Dallaire 2009 | Non‐comparative |
| Dankova 1995 | Serological study |
| Dashefsky 1990 | MMR not given independently. |
| Davis 1997 | MMR not given independently. |
| Dayan 2008a | Non‐comparative |
| Deforest 1986 | MMR given with DTP and OPV in different schedules. |
| Deforest 1988 | DTP/OPV +/‐ MMR versus placebo or without MMR |
| De Laval 2010 | Seroprevalence study |
| DeStefano 2000 | Duplicate data of db‐Taylor 1999] |
| Diaz‐Ortega 2010 | Non‐comparative |
| Dobrosavljevic 1999 | Case report |
| Dominguez 2008 | Surveillance study |
| Doshi 2009 | Effectiveness of measles‐containing vaccines was assessed, not MMR specifically. |
| Dos Santos 2002 | Non‐comparative |
| Duderstadt 2012 | Participants' ages (17 to 35 years) did not meet study inclusion criteria (6 months to 15 years). |
| Dyer 2010a | Commentary |
| Dyer 2010b | Commentary |
| Elphinstone 2000 | No data |
| Englund 1989 | MMR not given independently. |
| Fitzpatrick 2007 | Commentary |
| Fletcher 2001 | Commentary |
| Garrido Lestache 1992 | Non‐comparative |
| Geier 2004 | Uncertain MMR focus, mixed with thimerosal |
| Gerber 2009 | Review |
| Goodson 2010 | Monovalent measles vaccine |
| Griffin 1991 | Non‐comparative |
| Grilli 1992 | Comparison of different types of measles in MMR |
| Hasrina 2017 | Poster. No effectiveness or safety data |
| Hilton 2009 | Content analysis |
| Hindiyeh 2009 | No outcomes of interest. The study reported on serological data. |
| Höhle 2011 | Monovalent varicella vaccine only |
| Hooker 2014 | Retracted publication |
| Hornig 2008 | Participants affected by gastrointestinal disturbance. |
| Hu 2007 | Non‐comparative |
| Hua 2009 | Association with Kawasaki disease. Tested for vaccines other than MMR |
| Huang 1990 | Serological data only |
| Huang 2009 | Case‐control study. Study of risk factors for mumps; does not provide effectiveness or safety data for mumps vaccination |
| Ipp 2003 | Head‐to‐head study of 2 MMR types |
| Jiang 2009 | Non‐comparative |
| Jones 1991 | Non‐comparative |
| Just 1985 | Comparison of different types of MMR; CCT with serological outcomes |
| Just 1986 | Compared MMR +/‐ varicella vaccine |
| Just 1987a | Compared MMR +/‐ OPV |
| Just 1987b | Compared MMR +/‐ DTP |
| Kaaber 1990 | Compared MMR with or without other vaccine versus other vaccines (DTP and OPV) |
| Karim 2002 | Case report |
| Kaye 2001 | Non‐comparative |
| Kazarian 1978 | Case report |
| Khalil 2005 | Cross‐sectional study |
| Kiepiela 1991 | RCT investigating 2 types of measles vaccine |
| Kulkarni 2005 | Review |
| Kurtzke 1997 | Case‐control of exposure to anything/measles vaccine and multiple sclerosis |
| Kutty 2014 | Economic evaluation |
| Latasa 2019 | Insufficient information: epidemiological study of mumps incidence |
| Lee 1998 | Commentary |
| Lee 2007 | Non‐comparative |
| Lucena 2002 | No comparator |
| Maekawa 1991 | Non‐comparative |
| Maguire 1991 | Non‐comparative |
| Majwala 2018 | Measles vaccine type not specified |
| Mantadakis 2010 | Review |
| Marshall 2016 | Head‐to‐head study of 2 MMRVs |
| Matter 1995 | Non‐comparative |
| Matter 1997 | Serological data only |
| Meissner 2004 | Review |
| Miller 1983 | Non‐comparative; egg allergy |
| Miller 1993 | Non‐comparative |
| Min 1991 | Compared 2 MMR types |
| Minekawa 1974 | Non‐comparative |
| Mommers 2004 | MMR and all other childhood vaccines, indistinguishable comparison |
| Mupere 2006 | MMR vaccine not included. |
| Nalin 1999 | Serological data only |
| Narwaney 2017 | Non‐comparative |
| Nicoll 1998 | Commentary |
| Ntshoe 2013 | Vaccine type not reported. |
| O'Brien 1998 | Letter |
| O'Connor 2019 | Insufficient information to assess vaccine efficacy; there were no unvaccinated children in the group |
| Ong 2006 | Review |
| Patja 2000 | Non‐comparative |
| Patja 2001 | Non‐comparative |
| Pekmezovic 2004 | MMR not included. |
| Peltola 1998 | Non‐comparative case series |
| Peltola 2007 | Review |
| Petridou 1997 | Case‐control investigation that included all 153 incident cases of leukaemia ascertained throughout the country during 1993 and 1994, and 2 hospital controls for every case matched for gender, age, and place of residence. Data on MMR vaccination are presented as "total viral vaccination shots" (measles, mumps, rubella, hepatitis B vaccines; each antigen counted as a distinct shot). |
| Puvvada 1993 | Non‐comparative case series |
| Rajantie 2007 | Non‐comparative. Unclear study design |
| Roost 2004 | Cross‐sectional study |
| Sabra 1998 | Commentary |
| Saraswathy 2009 | Serological data only |
| Scarpa 1990 | Non‐comparative |
| Schaffzin 2007 | Differences between 2 subpopulations in the study were not taken into account. Partially outside age parameters for this review. Effectiveness was calculated cumulatively for campers (N = 368, age 7 to 15 years, mean 12 years, 366/368 previously immunised with 2 doses of mumps‐containing vaccine, only 2/368 with 1 dose) and staff members (N = 139, age 14 to 65 years, mean 21 years, of whom 74, 44, and 21 received respectively 2, 1, and no doses of a mumps‐containing vaccine). |
| Schettini 1989 | Serological data only |
| Schettini 1990 | Non‐comparative |
| Schmid 2008 | Non‐comparative |
| Schultz 2008 | Assessed a possible relationship between paracetamol and autism. Data were obtained via a parent survey; methods and results are questionable. |
| Schwarz 2010 | No treatment: measles + MMR vaccine |
| Schwarzer 1998 | Compared 2 types of MMR |
| Seagroatt 2003 | Measles vaccine type was unclear. |
| Shah 2017 | Serological data only |
| Shah 2018 | Insufficient information to detect efficacy of the third dose of the MMR vaccine |
| Sharma 2004 | Non‐comparative |
| Shinefield 2002 | MMR not given independently. |
| So 2008 | Korean language, abstract only in English |
| Spitzer 2001 | Commentary |
| Stetler 1985 | DTP vaccine |
| Stokes 1967 | Serological data only |
| Stratton 1994 | Review |
| Sugiura 1982 | Serological data only |
| Svanström 2010 | Non‐comparative |
| Tosun 2017 | Monovalent measles vaccine |
| Ueda 1995 | Compared 2 types of MMR |
| Vesikari 1979 | The study is written in Finnish, and reports on few epidemiological data not suitable for the objective of this review. |
| Vesikari 1984 | Compared 2 types of MMR |
| Wakefield 1998 | Retracted publication |
| Wakefield 1999a | Non‐comparative |
| Wakefield 1999b | No data |
| Wakefield 2000 | Non‐comparative |
| Walker 2011 | Non‐comparative |
| Willocks 2017 | Non‐comparative |
| Wilson 2003 | Systematic review |
| Wilson 2011 | Hospitalisation without specific definition made this endpoint too generic, therefore the study did not provide useful information on vaccine effectiveness or safety. |
| Woyciechowska 1985 | Not MMR |
| Yamashiro 1998 | Paricipants' ages did not meet review inclusion criteria. |
| Yu 2007 | Non‐comparative |
CCT: controlled clinical trial DTP: diphtheria, pertussis, and tetanus vaccine MMR: measles, mumps, rubella vaccine MMRV: measles, mumps, rubella, and varicella vaccine OPV: trivalent oral poliovirus vaccine RCT: randomised controlled trial