Table 1.

Analyzed variables in WT and Klf14 KO mice on chow and high fat diet.

	KW	Chow diet		post	High fat diet			post
	Sig.	Klf14 +/+	Klf14 −/−	Sig.	Klf14 +/+	Klf14 +/−	Klf14 −/−	Sig.
Body weight (g)	****	27.7 ± 1.9	28.6 ± 1.4	#	40.8 ± 6.8	45.0 ± 3.5	45.4 ± 3.1	#
Lean mass (g)	#	22.8 ± 1.5	23.7 ± 1.0		22.4 ± 2.5	23.7 ± 1.8	24.3 ± 2.2
Fat mass (g)	****	3.5 ± 1.3	3.4 ± 1.0	#	16.1 ± 4.3	18.8 ± 2.5	18.8 ± 3.3	#
Fasting-induced BW loss (g)	#	3.1 ± 0.4	2.9 ± 0.7		2.3 ± 0.5	2.7 ± 0.6	2.7 ± 0.5
AUC BW gain (g * week)	#	ND	ND		111 ± 37	130 ± 27	125 ± 25
Glucose (mmol/L)	**	5.0 ± 0.9	4.9 ± 0.5	#	7.6 ± 1.7	6.9 ± 1.9	6.7 ± 1.6	#
Insulin (ng/mL)	#	1.3 ± 0.8	1.3 ± 0.5		1.2 ± 0.3	1.1 ± 0.3	0.9 ± 0.2
Triglycerides (mmol/L)	***	0.48 ± 0.14	0.42 ± 0.26	#	0.28 ± 0.06	0.22 ± 0.06	0.25 ± 0.11	#
Glycerol (mmol/L)	#	0.36 ± 0.08	0.31 ± 0.08		0.34 ± 0.05	0.35 ± 0.05	0.37 ± 0.07
Cholesterol (mmol/L)	****	1.6 ± 0.2	1.5 ± 0.2	#	3.2 ± 0.8	3.2 ± 0.9	3.4 ± 0.7	#
HDL (mmol/L)	****	1.3 ± 0.2	1.2 ± 0.1	#	2.1 ± 0.3	2.1 ± 0.5	2.1 ± 0.4	#
ApoA-I (relative)	**	0.7 ± 0.2	0.7 ± 0.2	#	1.0 ± 0.2	ND	1.0 ± 0.2	#
Corticosterone (ng/mL)	#	179 ± 72	189 ± 74		229 ± 44	ND	221 ± 93
AUC IPGTT (dose 2g/kg; mmol/L * minute)	#	1132 ± 355	1039 ± 372		ND	ND	ND
AUC IPGTT (dose 1g/kg; mmol/L * minute)	#	ND	ND		1510 ± 449	1673 ± 587	1572 ± 364
Heart weight (mg)	#	126 ± 17	124 ± 12		111 ± 10	121 ± 17	124 ± 17
Liver weight (g)	**	1.12 ± 0.12	1.16 ± 0.22	#	1.47 ± 0.61	1.70 ± 0.51	1.66 ± 0.44	#

Values are the average ± SD. The values are sampled the following cohorts: Chow diet, 11 Klf14^+/+ and 6 Klf14^−/−; High fat diet, 8 Klf14^+/+, 11 Klf14^+/− and 15 Klf14^−/−. Statistical analysis of the data was performed using a nonparametric Kruskal-Wallis (KW) test with Dunn’s multiple comparison post tests for WT versus KO. AUC stands for area under the baseline corrected curve. Significance (Sig.) is indicated as follows

^#= not significant

^*< 0.05

^**< 0.01

^***< 0.001 and

^****< 0.0001. ND denotes not done.