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. 2021 Oct 10;2:31. doi: 10.1186/s43556-021-00053-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The effects of knocking down Cldn3 and Cldn4 on cell viability. Cell viability was assessed on human (a) LNCaP or (b) PC3 prostate cancer cells following siCldn3 or siCldn4 treatment. c Crystal violet staining was performed to visualize viable cells. Data are shown as mean ± SD of 3 to 4 independent experiments. *** represents p < 0.001 and **** represents p < 0.0001