Table 2. Endoscopic/PET scan/histologic characteristics by staging group.
Statistics presented as mean ± SD, median [P25, P75], N (column %).
p-values: at-test, bWilcoxon rank sum test, cPearson's chi-square test, dSatterthwaite t-test. GEJ: gastroesophageal junction; PET: positron-emission tomography; SUV: standardized uptake value.
| Factor | Overall (N=97) | Early stage (N=68) | Advanced stage (N=29) | p-value |
| GEJ location (cm) | 38.6 ± 2.8 | 38.4 ± 3.2 | 39.1 ± 1.8 | 0.18d |
| Hiatal hernia presence | 45 (46.4) | 38 (55.9) | 7 (24.1) | 0.004c |
| Hiatal hernia (cm) | 3.0 [2.0, 4.0] | 3.0 [2.0, 4.0] | 3.0 [2.0, 3.0] | 0.67b |
| Stricture | 6 (6.2) | 1 (1.5) | 5 (17.2) | 0.003c |
| Barret’s Esophagus presence | 46 (49.5) | 36 (56.3) | 10 (34.5) | 0.052c |
| Barret's segment length (cm) | 0.00 [0.00, 5.0] | 2.5 [0.00, 5.0] | 0.00 [0.00, 4.0] | 0.080b |
| Tumor size (cm) | 2.5 [2.0, 4.0] | 2.0 [1.4, 3.0] | 3.0 [2.5, 4.0] | 0.005b |
| Tumor size >2cm | 74 (76.3) | 47 (69.1) | 27 (93.1) | 0.011c |
| Tumor appearance | ||||
| Exophytic mass | 46 (47.4) | 26 (38.2) | 20 (69.0) | 0.002c |
| Nodule | 42 (43.3) | 37 (54.4) | 5 (17.2) | |
| Submucosal | 4 (4.1) | 1 (1.5) | 3 (10.3) | |
| Ulcer | 5 (5.2) | 4 (5.9) | 1 (3.4) | |
| Tumor circumference | ||||
| 0-33% | 67 (75.3) | 53 (84.1) | 14 (53.8) | 0.002b |
| 34-66% | 16 (18.0) | 9 (14.3) | 7 (26.9) | |
| 67-100% | 6 (6.7) | 1 (1.6) | 5 (19.2) | |
| PET scan findings | ||||
| SUV of primary tumor | 4.4 [3.0, 6.8] | 4.0 [2.9, 6.1] | 5.6 [4.5, 9.0] | 0.003b |
| SUV of primary tumor | ||||
| 0-2.5 | 17 (17.5) | 15 (22.1) | 2 (6.9) | 0.006b |
| 2.6-5 | 43 (44.3) | 33 (48.5) | 10 (34.5) | |
| >5 | 37 (38.1) | 20 (29.4) | 17 (58.6) | |
| SUV of primary tumor | ||||
| 5.0 or less | 60 (61.9) | 48 (70.6) | 12 (41.4) | 0.007c |
| Over 5.0 | 37 (38.1) | 20 (29.4) | 17 (58.6) | |
| Nodes | ||||
| Negative | 78 (80.4) | 55 (80.9) | 23 (79.3) | 0.86c |
| Regional Positive | 19 (19.6) | 13 (19.1) | 6 (20.7) | |
| SUV of lymph nodes | 0.00 [0.00, 0.00] | 0.00 [0.00, 0.00] | 0.00 [0.00, 0.00] | 0.96b |
| SUV of lymph nodes | ||||
| 0-2.5 | 84 (86.6) | 59 (86.8) | 25 (86.2) | 0.98b |
| 2.6-5 | 9 (9.3) | 5 (7.4) | 4 (13.8) | |
| >5 | 4 (4.1) | 4 (5.9) | 0 (0.00) | |
| Pathology findings of resection specimens: | ||||
| Histologic grade | ||||
| Well differentiated | 17 (18.3) | 16 (25.0) | 1 (3.4) | 0.012c |
| Moderately differentiated | 44 (47.3) | 31 (48.4) | 13 (44.8) | |
| Poorly differentiated | 32 (34.4) | 17 (26.6) | 15 (51.7) | |
| Tumor greatest dimension (cm) | 2.0 [0.80, 3.4] | 1.3 [0.70, 2.5] | 3.0 [2.5, 4.2] | <0.001b |
| Positive resection margins | 11 (11.3) | 8 (11.8) | 3 (10.3) | 0.84c |
| Lymphovascular invasion | 35 (37.6) | 14 (21.5) | 21 (75.0) | <0.001c |
| Perineural invasion | 22 (25.9) | 5 (8.3) | 17 (68.0) | <0.001c |