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. 2020 Dec 30;1:19. doi: 10.1186/s43556-020-00023-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — RAD50 depletion and cisplatin sensitivity in PEO4 cells. a RAD50_KD in PEO4 cells. b Quantification of western blot showing RAD50 depletion in PEO4 cells. c Cisplatin sensitivity in A2780cis control and PEO4_RAD50_KD cells (clonogenic assay). d The percentage of γH2Ax positive cells by flow cytometry in control and RAD50_KD_ PEO4 cells treated with cisplatin compared to scrambled controls. e Cell cycle analysis by flow cytometry in control and RAD50_KD_ PEO4 cells treated with cisplatin compared to scrambled controls. f Annexin V analysis by flow cytometry in control and RAD50_KD_ PEO4 cells treated with cisplatin compared to scrambled controls. UN = untreated cells. T = treated cells. g RAD50_KD in A2780cis cells using second construct. h Quantification of western blot showing RAD50 depletion in A2780cis cells. i Cisplatin sensitivity in A2780cis control and A2780cis_RAD50_KD cells (clonogenic assay) using second construct. UN = untreated cells. T = treated cells