Fig. 1.

DNA damage response inhibitors do not increase IFN or NF-kB reporter activation in THP1-Dual cells. a THP1-Dual cells were treated with 12.5 μg/mL cGAMP, 2.5 μM V158411 (Chk1i), VX-970 (ATRi), AZD1775 (Wee1i) or 2.2–20 μM KU-60019 (ATMi) or NU-7441 (DNA-PKcsi) for 24 h and reporter activity determined as described. Mean of 2 independent wells. b THP1 or Jurkat cells were treated with the indicated concentrations of V158411 for 24 h. c THP1-Dual cells were treated with the indicated concentrations of cGAMP or V158411 for 24 h