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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Clin Pharmacol Ther. 2021 Jul 12;110(3):662–676. doi: 10.1002/cpt.2333

Figure 1. Overview of the gene locus and allelic variation.

Figure 1

Panel (a) provides a graphical overview of the CYP2C gene locus containing CYP2C18, CYP2C19, CYP2C9, and CYP2C8. The latter is encoded on the reverse strand (arrow) while the other three genes are encoded on the forward strand. CYP2C9 is composed of nine exons, covering 51.5 kb (GRCh37, 96,698,415 – 96,749,147; GRCh38, 94,938,658 – 94,990,091). Panel (b) shows the core sequence variations defining CYP2C9*2,*3, *5, *6, *8, *10, *11, *12, *13 and *15 representing Tier 1 and Tier 2 alleles per AMP allele recommendation guidelines (34). p.R144C is also present on CYP2C9*35 and *61 and is thus not unique to CYP2C9*2. Likewise, p.I359L is also part of several haplotypes, i.e., CYP2C9*3, *18, and *68.