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. Author manuscript; available in PMC: 2021 Nov 22.
Published in final edited form as: Parkinsonism Relat Disord. 2021 Jun 29;89:63–72. doi: 10.1016/j.parkreldis.2021.06.023

Fig. 1.

Fig. 1.

Pedigrees and segregation analysis. A- and B- Pedigrees of Family 1 (F1) and Family 2 (F2), respectively, harbouring the SNCA c.215C > T (p.Thr72Met) variant. Filled black symbols indicate PD patients, white symbols unaffected members, and green halos around symbols show subjects with polyneuropathy (HMSN2). Arrows indicate the index cases. All the available genotypes for the SNCA c.215C and LRSAM1 c.2005G positions are given for each of the tested family members. AAO: onset age of PD; AAD: age at death; AAE: age at last examination; n. k.: not known; SNCA: SNCA c.215C > T (p.Thr72Met); LRSAM1: LRSAM1 c.2005G > T (p.Glu669*); +/−: heterozygous carrier; −/−: non-carrier. C- Representative electropherogram of one PD case shows the heterozygous SNCA c.215C > T (p.Thr72Met) variant, as compared to reference (wild-type) sequence.