KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| rabbit α-dmXNP15879 antibody | Emelyanov et al., 2010 | N/A |
| rabbit α-dmHIRA antibody | Konev et al., 2007 | N/A |
| rabbit α-dmASF1 antibody | Jessica Tyler, Weill Cornell Medicine | N/A |
| mouse α-tubulin antibody | Sigma Aldrich | RRID: AB_477579 |
| HRP-coupled secondary antibody mouse | Sigma Aldrich | RRID: AB_259755 |
| HRP-coupled secondary antibody rabbit | Sigma Aldrich | RRID: AB_258103 |
| Chemicals, peptides, and recombinant proteins | ||
| NaCl | Roth | Cat#39572 |
| HEPES-KOH | Roth | Cat#9105.3 |
| EDTA | Sigma Aldrich | Cat#E6760 |
| NP-40 | Sigma Aldrich | Cat#I3021 |
| UltraPure Sucrose | Invitrogen | Cat#15503022 |
| Propidium iodide | Sigma Aldrich | Cat#P4170 |
| MgCl2 | Roth | Cat#2189,1 |
| H2SO4 | Merck | Cat#30743 |
| Acetone | Roth | Cat#9372.2 |
| Tris base | Sigma Aldrich | Cat#GE17-1321-01 |
| Trichloroacetic acid (TCA) | Merck | Cat#8071000 |
| Ammonium bicarbonate (ABC) | Merck | Cat#101131 |
| Acetonitrile (ACN) | Bartlet | Cat#CL0001752500 |
| Dithiothreitol (DTT) | Roth | Cat#6908.3 |
| Iodoactamide (IAA) | Sigma Aldrich | Cat#I-6125 |
| Pepsin | Promega | Cat#V1959 |
| SDS | Roth | Cat#2326.5 |
| Glycerol | Roth | Cat#3783.1 |
| 2-mercapto-ethanol | Roth | Cat#4227.3 |
| TRI Reagent | Sigma Aldrich | Cat#T-9424 |
| DNase I | New England Biolabs | Cat#M0303 |
| Igepal CA-630 | Sigma Aldrich | Cat#I8896 |
| cOmplete, EDTA-free protease inhibitor coctail | Roche | Cat#COEDTAF-RO |
| Q5 High-Fidelity DNA Polymerase | New England Biolabs | Cat#E0555 |
| Tegosept | Sigma Aldrich | Cat#54680 |
| Rapamycin from Streptomyces hygroscopicus | Sigma Aldrich | Cat#R0395 |
| Triton X-100 | Acros Organics | Cat#215682500 |
| E133 brilliant blue food coloring | Sigma Aldrich | Cat#80717 |
| Porcine trehalase | Sigma Aldrich | Cat#T8778 |
| Amyloglycosidase | Sigma Aldrich | Cat#A7095 |
| Critical commercial assays | ||
| Luna® Universal qPCR Master Mix | New England Biolabs | Cat#M3003 |
| LunaScript RT SuperMix Kit | New England Biolabs | Cat#E3010 |
| GE Healthcare Amersham ECL Prime Western-Blot Detection | GE Healthcare | Cat#28980926 |
| Illumina Tagment DNA Enzyme and Buffer | Illumina | Cat#20034197 |
| Monarch Genomic DNA Purification Kit | New England Biolabs | Cat#T3010 |
| Monarch PCR & DNA Cleanup Kit | New England Biolabs | Cat#T1030 |
| Glucose (HK) assay kit | Sigma Aldrich | Cat#GAHK20 |
| Serum Triglyceride Detection Kit | Sigma Aldrich | Cat#TR0100 |
| Deposited data | ||
| ATAC-seq raw data | Sequence Read Archive SRA | SRA: PRJNA730408 |
| RNA-seq data | Gene Expression Omnibus repository | GEO: GSE146392 |
| Experimental models: organisms/strains | ||
| Drosophila melanogaster: Chd1 WT/WT: w1118; Chd11, P{Chd1+} / Df(2L)Exel7014, P{Chd1+} | Morettini et al., 2011 | N/A |
| Drosophila melanogaster: Chd1−/−: w1118; Chd11 / Df(2L)Exel7014 | Konev et al., 2007 | N/A |
| Drosophila melanogaster: UAS-Chd1: w1118; Chd11, P{w+,UASt-Chd1} / Df(2L)Exel7014 | Konev et al., 2007 | N/A |
| Drosophila melanogaster: elav-Gal4: w1118; Chd11 / Df(2L)Exel7014; P{w+, elav-Gal4}/+ | this study | N/A |
| Drosophila melanogaster: Chd1elav: w1118; Chd11, P{w+,UASt-Chd1} / Df(2L)Exel7014; P{w+, elav-Gal4}/+ | this study | N/A |
| Drosophila melanogaster: H3.3KO: w1118, delH3.3B(w+), hsp-Flp; Df/(2L)H3.3A/SM6B | Hödl and Basler, 2009 | N/A |
| Drosophila melanogaster: Ssm185b: w1118, ssm 185b/FM7c | Loppin et al., 2000 | N/A |
| Drosophila melanogaster: UAS-2xsNPF: w1118; UAS-sNPF; UAS-sNPF | Lee et al., 2004 | N/A |
| Drosophila melanogaster: Chd1sNPF: w1118; Chd1, UAS-sNPF/Df(2L)Exel7014; P{w+, elav-Gal4}/UAS-sNPF | this study | N/A |
| Drosophila melanogaster: Oregon R: w+O | this study | N/A |
| Oligonucleotides | ||
| Ad1_noMX | Buenrostro et al., 2013 | N/A |
| Ad2.1-Ad2.3 | Buenrostro et al., 2013 | N/A |
| Ad2.7-Ad2.12 | Buenrostro et al., 2013 | N/A |
| Software and Algorithms | ||
| Skyline Spectral Library | MacCoss Lab Software | v20.1.0.155 |
| Fusion Software | PeqLab | v15.17 |
| R | https://www.r-project.org | v3.6.1 |
| deepTools suite | Ramírez et al., 2014 | v3.5.1 |
| GraphPad Prism | GraphPad | v8.2.1 |