Table 3.
Percentage of mutations mapped to the protein domains
| Cancer type | COSMIC mutation data | No. of mutated protein domains | No. of mutations mapped to domains | Percentage |
|---|---|---|---|---|
| Adrenal | 10 868 | 1322 | 6020 | 55.39 |
| Biliary | 69 570 | 3377 | 34 141 | 49.07 |
| Bone | 34 139 | 2594 | 16 957 | 49.67 |
| Brain | 129 130 | 3791 | 66 615 | 51.58 |
| Breast | 285 712 | 4901 | 140 430 | 49.15 |
| Cervix | 55 642 | 3280 | 26 009 | 46.74 |
| Endometrium | 282 168 | 4952 | 139 785 | 49.53 |
| Eye | 2085 | 209 | 1376 | 65.99 |
| Kidney | 112 577 | 4117 | 56 746 | 50.40 |
| Large interstine | 1 039 252 | 5327 | 518 025 | 49.84 |
| Liver | 409 309 | 5093 | 195 589 | 47.78 |
| Lung | 670 483 | 5190 | 340 620 | 50.80 |
| Esophagus | 214 073 | 4423 | 106 436 | 49.71 |
| Ovary | 70 245 | 3402 | 36 772 | 52.34 |
| Pancreas | 126 512 | 3771 | 67 563 | 53.40 |
| Prostate | 151 061 | 4286 | 73 305 | 48.52 |
| Skin | 921 194 | 5217 | 453 763 | 49.25 |
| Stomach | 276 849 | 4822 | 137 911 | 49.81 |
| Testis | 1179 | 198 | 668 | 56.65 |
| Thyroid | 258 180 | 4195 | 122 263 | 47.35 |
| Urinary | 235 499 | 4714 | 114 324 | 48.54 |