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. 2021 Nov 8;12:753681. doi: 10.3389/fimmu.2021.753681

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Copyright © 2021 Du, Xiang, Xu, Cui, Pang, Xu, Mai and Ai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NRF2 is involved in the effect of LPS and AMPK pathway on SHP. (A) Relative luciferase activities of SHP promoter of large yellow croaker in HEK 293T cells after NRF2 overexpression. (B) Immunoblots for nuclear NRF2 in macrophages after LPS stimulation. (C) Immunoblots for nuclear NRF2 in macrophages after treatment with AMPK activator (AICAR). (D) Expression of shp in macrophages after treatment with LPS and NRF2 inhibitor (ML385). (E) Expression of shp in macrophages after treatment with AICAR and ML385. Data are presented as means ± SEMs, n = 3 replicate experiments. Significance was evaluated by one-factor ANOVA followed by Duncan’s multiple range test. Labeled means without a common letter differ, P < 0.05. AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; LPS, lipopolysaccharide; SHP, small heterodimer partner; GAPDH, glyceraldehyde-3-phosphate dehydrogenase. NRF2, nuclear factor-erythroid 2-related factor 2.