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. 2021 Nov 22;12:585. doi: 10.1186/s13287-021-02653-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Immunohistochemistry and semi-quantification results showing human embryonic stem cell transfection reverses the effect of AAV2-Htt171-82Q on microglia, astrocytes, and neurons. A, B The microglia and astrocytes were strongly activated by the infection of AAV2-Htt171-82Q (HD group) but less activated after cell transplantation (HD-ESC group). C The expression of caspase marker was increased in HD cells but get decreased after stem cell transplantation. D The neuronal marker (NeuN) was strongly expressed after cell transplantation compared with the HD group. E Oligodendrocytes marker expression in control, HD, and stem cell transplanted cell. *p < 0.05; **p < 0.01 significant difference between the indicated values (ANOVA)