Fig. 1.

Epithelial Postn is acquired in a subset of breast cancers. A Immunohistochemistry for the expression of Postn was performed on mammary tumors from a panel of Neu-driven murine breast cancer models and on human tissue microarrays (TMAs). The models used were the MMTV-NeuNDL model (n = 9), MMTV-NIC (n = 10) and MMTV-PyMT (n = 8). The human TMA contained 72 cores with various levels of HER2 expression. Scale bar = 200 µm. B Tumors were classified as acquired or non-acquired according to their epithelial expression of Postn and were represented as a proportion of the total number in a bar graph. C Clustered UMAP embedding of scRNA-seq data of 24,271 cells from five triple-negative breast cancer tumors. Data and cell-type annotations were acquired from Wu et al. [1]. D Identical UMAP showing the distribution of POSTN expression across the cell types comprised in the tumor. Expression values correspond to log-transformed counts per 10 k transcripts.) Summary of the average POSTN expression (Z-score) in each cell type and the percentage of cells with POSTN detection for each patient (P1-5)