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. 2021 Nov 21;19:381. doi: 10.1186/s12951-021-01127-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Role of CAFs in GC. a, b The RNA expression of fibroblast activation protein (FAP) between GC samples and normal gastric tissues using TCGA cohort data using unpaired (a) and paired (b) Student’s T test, respectively. c, d Kaplan–Meier overall survival analysis of GC patients in relation to FAP expression levels in TCGA cohort (c) and ACRG cohort (d). e, f The mRNA expression (e) and Kaplan–Meier overall survival (f) analysis of FAP in the GC and normal tissues using Zhejiang university cohort data. g Protein expression of FAP in 12 pairs of GC and adjacent normal gastric tissues by western blot analysis. (***p < 0.001)