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. 2021 Nov 21;19:381. doi: 10.1186/s12951-021-01127-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — PSN38@TPL-nsa antitumor efficiency in the CAFs-containing intraperitoneal tumor model. a Establishment of CAFs-containing intraperitoneal tumor model and schedule of in vivo antitumor experiments. b In vivo bioluminescence imaging of the mice after intravenous injections of PBS, TPL-nsa, PSN38, PSN38 + TPL-nsa and PSN38@TPL-nsa (n = 4). White dotted lines and arrows indicated the tumor nodules. c Quantitative analysis of bioluminescence imaging intensity on Day 12. d Body weight variation in the tumor-bearing mice during the experimental period (n = 4). e Western blotting analysis of PARP, caspase-3 and BAX family proteins of tumors in the different groups at the end of experiments. f Dissected intraperitoneal tumor nodules after humanitarian execution (n = 4). g, h The intraperitoneal tumor weights (g) and nodule numbers (h) in each group were statistically analyzed. All data are presented as mean ± SD. Unpaired Student’s t-test was used to analyze the data. (*p < 0.05; **p < 0.01; ***p < 0.001)