. Author manuscript; available in PMC: 2022 Aug 1.

Published in final edited form as: Ther Drug Monit. 2021 Aug 1;43(4):536–545. doi: 10.1097/FTD.0000000000000882

Table 1.

Cle = elimination clearance. Clthc->oh = metabolic clearance from THC to 11-OH-THC. Cloh->cooh = metabolic clearance from 11-OH-THC to THCCOOH. F_baseline, F_interval, and F_residence are the fraction of the assumed standard THC doses at recruitment, the interval before residential smoking, and in-residence smoking, respectively. CovMCQ_baseline, CovMCQ_interval, and CovTHC-WT are the scaling factors (sf: equation 1) for the self-report questionnaire daily doses (F_baseline) and weighed dose (F_residence), respectively.

	TYPICAL VALUE	±	SEE	ω²	±	SEE	SHRINKAGE
*THC*
Cle (L/min) Phase I Study	0.72	±	0.09	0.11	±	0.004
Cle (L/min) Current Study	0.58	±	0.07	^*


*11-OH-THC*
Clthc->oh (L/min) Phase I Study	0.36	±	0.02	0.024	±	0.3
Clthc->oh (L/min) Current Study	0.30	±	0.08	^*

*THCCOOH*
Cl_OH->COOH (L/min) Phase I Study	0.78	±	0.05	^*
Cl_OH->COOH (L/min) Current Study	0.75	±	0.20	0.03	±	0.09	0.68
Cle (L/min) Phase I Study	0.12	±	0.01	0.11	±	0.07
Cle (L/min) Current Study	0.08	±	0.01	0.22	±	0.08	0.18

*THC DOSE PARAMETERS*
Time (min) from beginning ad libitum smoking until first blood sample	14.0	±	2.8
F _baseline	0.37	±	0.13	0.62	±	0.10	0.04
F _residence	0.43	±	0.20	0.80	±	0.23	0.07
CovMCQ _baseline	0.77	±	0.08
CovTHC-WT _residence	0.40	±	0.08

ω² = inter-subject variability;

indicates ω² was fixed to Phase I study value. SEE = standard error of the estimate.