TABLE 1.
Patient characteristics
| CLAD (n = 24) | Control (n = 21) | P-value | |
|---|---|---|---|
| Age at transplant, median (IQR) | 52.5 (34.75–62.75) | 54 (37.0–63.5) | .59 |
| Female, n (%) | 10 (41.7) | 10 (47.6) | .16 |
| Transplant diagnosis, n (%) | .91 | ||
| Interstitial lung disease | 9 (37.5) | 7 (33.3) | |
| Cystic fibrosis | 7 (29.2) | 7 (33.3) | |
| Chronic obstructive pulmonary disease | 7 (29.2) | 6 (28.6) | |
| Retransplant | 1 (4.2) | 1 (4.8) | |
| Congenital | 1 (4.2) | 0 | |
| Cytomegalovirus serostatus | .44 | ||
| D+/R+ | 14 (36.4) | 8 (53.8) | |
| D−/R+ | 5 (22.7) | 5 (19.2) | |
| D+/R− | 5 (22.7) | 2 (7.7) | |
| D−/R− | 4 (18.2) | 5 (19.2) | |
| Anti-HLA donor-specific antibody | 6 (27.3) | 3 (11.5) | .27 |
| Acute rejection, n (%) | 9 (37.5) | 3 (14.3) | .11 |
| Acute infection, n (%) | 13 (52.4) | 0 | <.01 |
| Bacterial | 10 | — | |
| Viral | 1 | — | |
| Fungal | 2 | ||
| Days to CLAD, median (IQR) | 1645 (1133–1981) | — | |
| CLAD stage, n (%) | |||
| CLAD 1 | 15 (62.5) | — | |
| CLAD 2 | 3 (12.5) | — | |
| CLAD 3 | 6 (25.0) | — | |
| CLAD 4 | 0 |