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. Author manuscript; available in PMC: 2021 Nov 22.
Published in final edited form as: Nat Rev Endocrinol. 2018 Nov;14(11):637–655. doi: 10.1038/s41574-018-0076-3

Table 2 |.

Hormones and growth factors regulated by Pi

Factors Regulation by Pi Target organs Effect Blood Pi concentration Refs
FGF23 Up Kidney Renal Pi wasting and decreased synthesis of calcitriol Down 79
PTH Up Kidney and bone Renal Pi wasting, increased synthesis of calcitriol and release of Pi by bone resorption Down 286
Calcitriol Down Intestine and bone Increased intestinal Pi absorption and release of Pi by bone resorption Up 287
IGF1 Up Bone and kidney Increased Pi storage in bone mineral and increased renal Pi reabsorption Up (down) 99,288
Osteopontin Up Bone Increased Pi storage in bone mineral (Down) 98

FGF23, fibroblast growth factor 23; IGF1, insulin-like growth factor 1; Pi, inorganic phosphate; PTH, parathyroid hormone.