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. 2021 Nov 22;10(13):e12168. doi: 10.1002/jev2.12168

FIGURE 10.

FIGURE 10

Proposed model for how miR‐19a‐3p suppresses the immune function of CD8+ T cells. sEV‐related miR‐19a‐3p (regulated by NPM1mA) shuttles from leukemic cells to CD8+ T cells to inhibit SLC6A8‐mediated creatine import, thereby impairing the immune function of CD8+ T cells in AML