TABLE 1.
Baseline Demographic and Clinical Characteristics
| Gen 2 | |||
|---|---|---|---|
| Men (n=870) | Women (n=1035) | Significance | |
| Age, years | 66.28 (8.85) | 65.64 (9.17) | NS |
| Time interval between exam to NP/MRI evaluation, years | 0.51 (0.71) | 0.56 (0.78) | NS |
| Systolic blood pressure, mg/dL | 129.06 (16.68) | 127.51 (17.56) | NS |
| BMI, kg/m2 | 28.33 [25.81, 31.31] | 26.83 [23.65, 31.07] | * |
| Physical activity index | 35.57 (6.17) | 34.98 (5.10) | * |
| Total cholesterol, mg/dL | 175.70 (34.75) | 199.61 (35.96) | * |
| Triglycerides, mg/dL | 104 [75, 143] | 102 [73, 142] | NS |
| Education, n (%) | * | ||
| Up to high school degree | 242 (27.82) | 321 (31.01) | |
| Some college | 220 (25.29) | 365 (35.27) | |
| ≥College graduate | 408 (46.90) | 349 (33.72) | |
| Smoking, n (%) | 66 (7.59) | 101 (9.76) | NS |
| APOE4, n (%) | 192 (22.59) | 212 (20.99) | NS |
| Osteoporosis drug, n (%) | 44 (5.33) | 260 (25.92) | * |
| Antidepressant drug, n (%) | 69 (8.36) | 180 (17.93) | * |
| Lipid lowering drug, n (%) | 432 (49.66) | 406 (39.23) | * |
| Antihypertension drug, n (%) | 456 (52.47) | 433 (41.84) | * |
| Diabetes mellitus, n (%) | 160 (18.63) | 106 (10.44) | * |
| Prevalent CVD, n (%) | 139 (15.98) | 94 (9.08) | * |
| Prevalent AF, n (%) | 65 (7.47) | 39 (3.77) | * |
| Bone mineral density | |||
| Femoral neck BMD, g/cm2 | 0.96 (0.14) | 0.87 (0.13) | * |
| Femoral trochanter BMD, g/cm2 | 0.88 (0.14) | 0.71 (0.13) | * |
| Cognitive tests | |||
| LM-d recall score | 10.63 (3.81) | 11.65 (3.72) | * |
| VR-d recall score | 8.09 (3.33) | 8.1 (3.31) | NS |
| Trail making B-A, minutes | 0.36 [0.31, 0.39] | 0.36 [0.32, 0.40] | * |
| Similarities test score | 17.08 (3.80) | 16.79 (3.50) | NS |
| HVOT score | 25.0 [23.5, 27.0] | 26.0 [24.0, 27.0] | * |
| Brain MRI measures | |||
| TCBV, % of TCV | 75.97 (2.68) | 76.35 (2.50) | * |
| HPV, % of TCV | 0.53 (0.05) | 0.55 (0.05) | * |
| WMHV, % of TCV | 0.07 [0.04, 0.14] | 0.07 [0.04, 0.14] | NS |
AF indicates atrial fibrillation; APOE4, apolipoprotein E4 allele; BMD, bone mineral density; BMI, body mass index; CVD, cardiovascular disease; HPV, hippocampal volume; HVOT, Hooper Visual Organization test score; LM-d, logical memory delayed recall; MRI, magnetic resonance imaging; TCBV, total cerebral brain volume; TCV, total intracranial volume; VR-d, visual reproduction delayed; WMHV, white matter hyperintensity volume.
Data are mean (SD) or median [quartile 1 to quartile 3], unless stated otherwise.
*
Significant difference in characteristic between sexes (P<0.05).
Nonsignificant (P≥0.05).