TABLE 3.

Neuropsychological Outcomes

	Logical Memory Delayed Recall		Visual Reproduction Delayed Recall		Trail Making B-A (Log)		Similarities Test		HVOT(Log)
BMD Measure	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P
Men (M1 n=870, M2 n=857)
Femoral neck M1	1.31 [−0.43; 3.04]	0.140	1.70 [0.23; 3.16]	0.023	0.16 [0.05; 0.27]	0.003	0.67 [−0.95; 2.30]	0.417	−0.01 [−0.24; 0.22]	0.937
Femoral neck M2	1.32 [−0.46; 3.09]	0.145	1.64 [0.15; 3.12]	0.031	0.16 [0.05; 0.27]	0.004	0.89 [−0.77; 2.55]	0.291	−0.001 [−0.24; 0.24]	0.996
Femoral trochanter M1	0.71 [−0.98; 2.41]	0.410	1.24 [−0.20; 2.68]	0.091	0.15 [0.05; 0.26]	0.004	0.10 [−1.49; 1.69]	0.899	−0.05 [−0.28; 0.17]	0.645
Femoral trochanter M2	0.69 [−1.07; 2.44]	0.442	1.19 [−0.28; 2.67]	0.112	0.14 [0.04; 0.25]	0.008	0.24 [−1.4; 1.88]	0.774	−0.04 [−0.27; 0.20]	0.747
Women (M1 n=1035, M2 n=1015)
Femoral Neck M1	1.03 [−0.87; 2.93]	0.289	0.79 [−0.78; 2.36]	0.324	0.16 [0.04; 0.28]	0.010	0.30 [−1.38; 1.97]	0.727	0.20 [−0.05; 0.46]	0.117
Femoral Neck M2	1.08 [−0.89; 3.05]	0.283	0.47 [−1.15; 2.09]	0.569	0.16 [0.03; 0.29]	0.013	0.49 [−1.24; 2.23]	0.577	0.18 [−0.08; 0.44]	0.176
Femoral trochanter M1	2.32 [0.50; 4.14]	0.012	1.71 [0.20; 3.21]	0.026	0.07 [−0.05; 0.19]	0.254	−0.34 [−1.95; 1.26]	0.674	0.25 [0.004; 0.49]	0.046
Femoral trochanter M2	2.72 [0.8; 4.64]	0.006	1.53 [−0.05; 3.11]	0.058	0.08 [−0.04; 0.21]	0.182	−0.17 [−1.87; 1.52]	0.841	0.22 [−0.04; 0.48]	0.094

M1: model 1 adjusted for age, education, and time interval between exam and NP assessment.

M2: model 2 adjusted for age, education, time interval between exam and NP assessment, systolic blood pressure, antihypertensive medication use, smoking, diabetes, prevalent CVD, atrial fibrillation, total cholesterol, and triglycerides.

Bold values indicate statistical significance (P<0.05).

β corresponds to the change in cognitive test outcome associated with a 1 unit-increase in BMD.

CI indicates confidence interval; CVD, cardiovascular disease; HVOT, Hooper Visual Organization test; NP, neuropsychological.