TABLE 4.

Stratified Analysis by APOE4 Status in the Association Between BMD Measures and NP Test Performance (Where the Interaction was Significant)

	Trail Making B-A (Log)				HVOT (Log)
	APOE4		No APOE4		APOE4		No APOE4
BMD Measure	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P
Men (n=847)
Femoral neck	0.20 [0.01; 0.39]	0.043	0.15 [0.02; 0.28]	0.020	−0.36 [−0.85; 0.13]	0.150	0.14 [−0.13; 0.42]	0.308
Women (n=1005)
Femoral neck	0.40 [0.09; 0.71]	0.012	0.10 [−0.03; 0.24]	0.144	0.32 [−0.25; 0.89]	0.271	0.18 [−0.11; 0.47]	0.221

Adjusted for age, education, and time interval between exam and NP assessment.

Bold values indicate statistical significance (P<0.05).

β corresponds to the change in cognitive test outcome associated with a 1 unit-increase in BMD.

BMD indicates bone mineral density; CI, confidence interval; HVOT, Hooper Visual Organization test; NP, neuropsychological.