. Author manuscript; available in PMC: 2022 Feb 24.

Published in final edited form as: J Am Chem Soc. 2021 Feb 12;143(7):2729–2735. doi: 10.1021/jacs.1c00687

Table 1:

Optimization and Control Studies


Entry	Deviation from Standard Conditions	Yield 3 (%)
1	none	93
2	3 equiv. cyclooctane	73
3	0% CuCl₂	0
4	0% LiCl	79
5	in the dark	0
6	440 nm LED	66
7	30°C	45
8	under air	55
9	with 10% Cs₂CO₃	22
10	Irradiated 1 hour, then in the dark	14

Optimizations were performed on a 0.3 mmol scale using 5 equiv. of 1 and 1 equiv. of 2.