Figure 4.

(A) Analysis of the P. falciparum genome categorizing targets according to their predicted essentiality, druggability, and the presence of mammalian orthologs. The number of proteins in each category is shown in parentheses. (B) Analysis of high value targets, according to tool compounds, the presence of mammalian orthologs, and proof of concept in humans. The number of proteins in each category is shown in parentheses. Where there is only one protein in a category, it is stated explicitly. Most MalDA targets fall into the light blue or violet regions.