|
N-myristoyl transferase
(NMT) |
PF3D7_1412800 |
slow killer, challenges
with selectivity compared to the human
enzyme |
| P-type ATPase 4 (ATP4) |
PF3D7_1211900 |
multiple series under investigation in
the drug discovery pipeline |
| plasmepsin X |
PF3D7_0808200 |
multiple series under investigation
in the drug discovery pipeline |
| Niemann–Pick
type C1-related protein (NCR1) |
PF3D7_0107500 |
resistance risk, slow rate of kill and single-stage efficacy |
| dihydrofolate reductase (DHFR) |
PF3D7_0417200 |
clinically approved inhibitor; resistant parasites widespread
in the field |
| dihydroorotate dehydrogenase
(DHODH) |
PF3D7_0603300 |
multiple chemotypes
have been developed, and resistance can
arise readily |
| phosphatidyl inositol 4-kinase
(PI4K) |
PF3D7_0509800 |
multiple chemotypes
have been developed, and resistance can
arise readily |
