| cytosolic seryl-tRNA synthetase (SerRS) |
PF3D7_0717700.1 |
chemical starting points; TCP
fit |
| V-Type H+ ATPase |
includes
PF3D7_0406100, PF3D7_0806800, PF3D7_1311900 |
generate
chemical matter; understand resistance profile, druggability,
and TCP fit |
| heat shock protein 90 (HSP90) |
PF3D7_0708400 |
selectivity; more chemical starting
points |
| adenylyl cyclase beta (AC beta) |
PF3D7_0802600 |
TCP fit; more potent inhibitors;
selectivity |
| histone acetyltransferase GCN5
(GCN5) |
PF3D7_0823300 |
rate of kill; chemical
starting points |
| phosphodiesterase beta (PDEβ) |
PF3D7_1321500 |
resistance potential TCP fit; More
chemical starting points;
chemical tools for validation |
| aminopeptidase
P (APP) |
PF3D7_1454400 |
TCP fit; selectivity;
chemical tools |
| cysteine tRNA synthetase (CysRS) |
PF3D7_1015200.1 |
protein expressed; development
of assay; selectivity |
| hexose transporter
(HT) |
PF3D7_0204700 |
is selectivity versus
human orthologues possible? TCP fit;
activity against various life cycle stages |
