Appendix 5—table 3. A comparison of the pathway-reporter method and dual-reporter method for the multiscale model (Case (2)A above).

We consider fixed parameters values (that is, no extrinsic noise). As our theory predicts, the pathway-reporters correctly identify zero extrinsic noise.

Parameters						Simulation
(r)1-6 ${\lambda }_1$	${\mu }_1$	${\lambda }_2=K_N$	$K_M$	$K_P$	${\delta }_P$	Pr (MP)	Pr (NP)	DR (Mat)
2	2	400	20	2	0.1	$0.02\pm 0.003$	$0.00\pm 0.01$	$0.00\pm 0.002$
4	20	1210	20	2	0.1	$0.02\pm 0.003$	$0.01\pm 0.01$	$0.00\pm 0.01$