Appendix 5—table 5. A comparison of the pathway-reporter method and dual-reporter method for the multiscale model with a fixed duration of maturation (Case (3)A).

Here the time to maturation $T_{\mathrm{mat}}$ is chosen to be consistent with the mean of the stochastic maturation time used in our other models (where the maturation time is exponentially distributed). We consider all rate parameters to be constant, that is, there is no extrinsic noise. Pathway-reporters correctly identify the zero extrinsic noise contribution.

Parameters						Simulation
(r)1-6 ${\lambda }_1$	${\mu }_1$	${\lambda }_2=K_N$	$T_{\mathrm{mat}}$	$K_P$	${\delta }_P$	Pr (MP)	Pr (NP)	DR (Mat)
2	2	400	0.05	2	0.1	$0.02\pm 0.004$	$0.00\pm 0.01$	$0.00\pm 0.01$
4	20	1210	0.05	2	0.1	$0.02\pm 0.003$	$0.00\pm 0.01$	$0.00\pm 0.01$