Appendix 5—table 8. A comparison of the pathway-reporter method and dual-reporter method for the multiscale model with Erlang-distributed maturation times and cell-cycle effects (Case (4)B).

The Erlang distributed maturation time is chosen as in Appendix 5—tables 7. For each of the parameters ${\lambda }_1,{\mu }_1,K_P,{\delta }_P$, we selected a scaled ${\displaystyle \mathrm{B}\mathrm{e}\mathrm{t}\mathrm{a}(5,6)}$ distribution, with squared coefficient of variation ${\eta }^2=0.1$; the scaling is chosen in each case to achieve a mean value equal to the parameter value. The parameter ${\lambda }_2=K_N$ is given the noise distribution ${\displaystyle \mathrm{B}\mathrm{e}\mathrm{t}\mathrm{a}(3,6)}$, which has a slightly higher coefficient of variation ${\eta }^2=0.2$.

Means						Simulation
(r)1-6 ${\lambda }_1$	${\mu }_1$	${\lambda }_2=K_N$	$T_{\mathrm{mat}}$	$K_P$	${\delta }_P$	Pr (MP)	Pr (NP)	DR (Mat)
2	2	400	0.05	2	0.1	$0.21\pm 0.04$	$0.18\pm 0.04$	$0.23\pm 0.02$
4	20	1210	0.05	2	0.1	$0.34\pm 0.05$	$0.30\pm 0.12$	$0.36\pm 0.02$