Fig. 2.

Neuroinflammation in Alzheimer’s disease. Figure 2 shows the hyperactive glial cells including astrocytes and microglia upon interaction between Aβ and tau. Microglia and astrocytes are the major cells in the brain responsible for inflammatory responses. Due to the activation of glial cells various pro-inflammatory mediators are released which direct more inflammatory molecules at the site of injury leading to exaggerated inflammatory response in brain called neuroinflammation