Table 1.
Demographic and Clinical Characteristics of Study Population.
| Non-Glaucomatous Eyes | Open Angle Glaucoma Eyes | P value | |
|---|---|---|---|
| By Participant | n = 92 | n = 174 | |
| Mean Age, years | 65.5 (64.1 to 67.0) | 63.5 (61.2 to 65.8) | 0.222 |
| Gender, no. female (% female) | 49 (53.3) | 81 (46.8) | 0.318 |
| Self-Reported Hypertension, no. (%) | 33 (35.9) | 64 (36.8) | 0.883 |
| Self-Reported Diabetes Mellitus, no. (%) | 13 (14.1) | 24 (13.8) | 0.940 |
|
| |||
| By Eye | n = 123 | n = 252 | |
|
| |||
| C/D Ratio | 0.59 (0.53 to 0.65) | 0.78 (0.75 to 0.80) | <0.001 |
| IOP, mm Hg | 14.2 (12.9 to 15.6) | 13.7 (13.2 to 14.2) | 0.186 |
| 24–2 MD, Db | −1.17 (−2.96 to 0.642) | −5.77 (−6.45 to −5.10) | <0.001 |
| 24–2 PSD, Db | 2.10 (0.992 to 3.22) | 5.01 (4.60 to 5.42) | <0.001 |
| OCT RNFL Signal Strength | 8.3 (7.9 to 8.7) | 8.3 (8.2 to 8.4) | 0.898 |
| OCT GCIPL Signal Strength | 9.0 (8.7 to 9.4) | 8.9 (8.8 to 9.0) | 0.231 |
| Peripapillary OCTA Signal Strength | 9.5 (9.2 to 9.8) | 9.4 (9.2 to 9.5) | 0.087 |
| Macular OCTA Signal Strength | 9.6 (9.3 to 9.9) | 9.3 (9.2 to 9.4) | 0.001 |
| OCT Metrics | |||
| RNFL, µm | 88.0 (83.1 to 92.9) | 73.2 (71.5 to 74.9) | <0.001 |
| GCIPL Thickness, µm | 77.3 (73.6 to 80.9) | 68.3 (66.9 to 69.7) | <0.001 |
| Peripapillary OCTA Metrics | |||
| Pvad | 0.348 (0.324 to 0.371) |
0.282 (0.275 to 0.291) |
<0.001 |
| pPDZ | 0.423 (0.409 to 0.437) | 0.396 (0.391 to 0.401) | <0.001 |
| Macular OCTA Metrics | |||
| mVAD | 0.471 (0.451 to 0.491) | 0.426 (0.419 to 0.434) | <0.001 |
| mVSD | 0.186 (0.177 to 0.195) |
0.166 (0.163 to 0.170) |
<0.001 |
| mPDZ | 0.427 (0.408 to 0.445) | 0.414 (0.410 to 0.421) | 0.034 |
| mVDZ | 17.8 (17.1 to 18.5) | 17.2 (17.0 to 17.4) | 0.009 |
All demographic and clinical characteristics in this table are presented as mean (95% confidence interval) or frequency (percent). Participant-specific characteristic comparisons are based on t-tests and chi-square tests. Eye-specific characteristics adjusted for inter-eye correlation using linear mixed-effects modeling. Commercial OCTA metrics are separated from custom OCTA metrics with a horizontal black bar. C/D = cup-to-disc, IOP = intraocular pressure, MD = mean deviation, PSD = pattern standard deviation, OCT = optical coherence tomography, OCTA = OCTA, RNFL = retinal nerve fiber layer, GCIPL = ganglion cell-inner plexiform layer, pVAD = peripapillary vessel area density, pPDZ = peripapillary perfusion density, mVAD = macular vessel area density, mVSD = macular vessel skeleton density, mPDZ = macular perfusion density, mVDZ = macular vessel density.